Chytil in great chance shortly before the end of the opening half but missed the empty target from sharp angle after dodging goalkeeper.
After 67 minutes Mojmír Chytil onterrupted a Bohemians build-up, decided to fire in a 3 on 1 counter attack and sent the ball past Jedlička to the far post.
Oscar could add third at the end, but Jedlička blocked his effort from below the crossbar.
With Sparta losing 1-3 at Mladá Boleslav, Slavia moved to the top spot of the league table. The Red-Whites remain the only unbeaten team of the 2023/24 league season.
Next game is played on Sunday, 5 November, at home against Viktoria Plzeň.
Jedlička – Křapka, Vondra, Hůlka – Köstl, Smrž (71. Hrubý), Jánoš (83. Jindřišek), Dostál – Hála (71. Mužík), Puškáč (59. Kozák), Matoušek (83. Shejbal)
Mandous – Vlček, Ogbu, Bořil – Tomič (90. Hromada), Oscar, Zafeiris (78. Wallem), Provod – Jurečka (62. Jurásek), Chytil (78. Sinyan) – Tijani (90. van Buren)